These are some of the human Spaceship (and space station) designs that made it into Gunfire Games' VR title; From other Suns. I spent a fair bit of time working on the characters and ships for the game.
After nailing down an overall idea with pencil and paper; I used Sketchup to design the base proportions for most of these, then built out secondary forms and detail with line in photoshop.
Many of these ships needed to have multiple stages/variations to help make each encounter feel unique. Or in the case of the station/base to be entirely modular.